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William Jagust

neurologist: Biosciences

Media contact: Dan Krotz, 510-486-4019, dakrotz@lbl.gov

 

William is a clinical neurologist who also serves as the Lab's Deputy Head of the Radiotracer Development & Imaging Technology department.  For over three decades he has conducted research using brain imaging (PET and MRI techniques in particular) to investigate brain aging and dementia.

He is also a professor of Public Health and Neuroscience at UC Berkeley and adjunct professor of Neurology at UC San Francisco.

Recent research

William's reseach is aimed at understanding the structural, functional and biochemical basis of brain aging and neurodegenerative diseases associated with brain aging.  He uses the techniques of positron emission tomography (PET), magnetic resonance imaging (MRI), functional MRI, and neuropsychology and cognitive neuroscience to study normal older people, and patients with neurodegenerative disorders of Alzheimer's disease and related dementias and Parkinson's disease.  

One major project in the laboratory uses PET imaging of beta-amyloid to detect deposition of this protein and its effects on cognition in aging, with an aim at understanding neural processes in the earliest stages of Alzheimer’s disease.  

Another major project uses PET to measure aspects of the brain dopamine system in an effort to understand its role in supporting neural systems in cognition and aging.  

Jagust is also the leader of the PET core of the Alzheimer’s Disease Neuroimaging Initiative, a public-private partnership jointly funded by NIH and industry, which is aimed at developing and validating a range of biomarkers for the study of Alzheimer’s disease and the speeding of drug development.  This project enrolls subjects at 60 sites in North America who undergo longitudinal study with a range of biomarkers including PET scans of glucose metabolism and beta-amyloid. Jagust’s lab leads data acquisition and analysis aspects of this core.

Education

Resident (Neurology), Boston University Medical Center, Boston, MA, 1980-1983

Intern (Medicine), St. Elizabeth's Hospital, Boston, MA, 1978-1980

M.D. (Medicine), SUNY Stony Brook, Stony Brook, NY, 1978 

B.A. (Psychology), Reed College, Portland, OR, 1974

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last updated: 2017-08-04 10:31:33